2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-(iodomethyl)-, 1,1-dimethylethyl ester - Names and Identifiers
2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-(iodomethyl)-, 1,1-dimethylethyl ester - Physico-chemical Properties
Molecular Formula | C14H24INO3
|
Molar Mass | 381.25 |
Density | 1.46 |
Boling Point | 416.8±30.0 °C(Predicted) |
pKa | -0.93±0.40(Predicted) |
Storage Condition | Room Temprature |
2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-(iodomethyl)-, 1,1-dimethylethyl ester - Introduction
N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro [4.5] decane is an organic compound with the molecular formula C15H25INO2 and an iodomethyl group and an oxygen heterocycle in its structure. The following is a description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: Colorless or light yellow solid
-Melting point: about 70-75 degrees Celsius
-Solubility: Soluble in common organic solvents, such as ether, alcohol, ketone, etc
Use:
- N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro [4.5] decane is usually used as an intermediate compound in organic synthesis and used in the synthesis of other organic compounds.
-It can be used as a protecting group or functional group transfer reagent in organic synthesis reactions.
Method:
the preparation method of N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro [4.5] decane is generally carried out by the following steps:
1. 3-bromopropanesulfonic acid and methyl iodide are added to a reaction vessel to generate 3-(iodomethyl) propanesulfonic acid.
2. Condensation reaction of 3-(iodomethyl) propanesulfonic acid with 2-butanol to generate N-BOC-3-(iodomethyl)-2-butyric acid.
3. finally, N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro [4.5] decane was obtained by the reaction of cuprous chloride and liquid ammonia.
Safety Information:
- N-BOC-3-(iodomethyl)-2-oxa-8-azaspiro [4.5] decane is unstable at room temperature and should be stored under low temperature and dry conditions.
-When using, please follow the correct laboratory procedures and bring appropriate personal protective equipment, such as laboratory gloves and protective glasses.
-This compound may be irritating and damaging to the eyes, skin and respiratory tract. Avoid direct contact or inhalation of its dust.
-If accidentally inhaled or exposed to the compound, rinse immediately with plenty of water and seek medical attention if necessary.
Last Update:2024-04-10 22:29:15